Nutraceuticals may represent a valuable alternative or adjunct to conventional prescription drugs in such a context. However, lifestyle interventions are difficult to maintain in the long term and medications may be associated with side effects. switch to a healthier diet and increased physical activity), and use of various medications. Recommendations include lifestyle interventions (i.e. Preventing or delaying progression to T2D in this population is therefore a major public health issue and therapeutic goal. Moreover, micro- and macrovascular damage is already present in pre-diabetic individuals. Individuals with impaired fasting glucose homeostasis and/or impaired glucose tolerance (referred to as pre-diabetic) are at high risk for the future development of T2D, especially if they are also overweight. ![]() Type 2 diabetes (T2D) constitutes a growing global epidemic worldwide and is associated with numerous disabling and life-threatening complications, as well as a major economic burden. ![]() The above declarations have no effect on the authors' adherence to all the PLOS ONE policies on sharing data and materials. ![]() Other: CV has received consultancy fees from AstraZeneca and Sanofi, support for travel and congress inscription from Novonordisk and Sanofi, and research materials from AstraZeneca JPB has received speaker fees from the European Group for the Study of Insulin Resistance (EGIR) and from Servier and a research grant from the Association Nationale de la Recherche sur le SIDA (ANRS) SF has received support for congress attendance from Beckman Coulter the other authors declare no conflict of interest. The tested product was marketed before the beginning of the study. There are no patents or products in development to declare. SB, AG and CL are employed by PiLeJe AC received a grant from PiLeJe, OA and YL received fees for data management and other study procedures on the behalf of PiLeJe, MS is employed by AdipoPhYt at the time of the study. The funders participated in the design and monitoring of the study, but had no role in data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: PileJe (Saint-Laurent-des-Autels, France) provided funding towards this study. ![]() This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are available in the paper and its Supporting Information files.įunding: This work was supported by PileJe (Saint-Laurent-des-Autels, France), the study sponsor, as well as by INSERM and Pierre and Marie Curie University (Paris, France). Received: OctoAccepted: AugPublished: September 25, 2015Ĭopyright: © 2015 Liu et al. Fairbanks School of Public Health, UNITED STATES PLoS ONE 10(9):Įditor: Yiqing Song, Indiana University Richard M. (2015) A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. Citation: Liu Y, Cotillard A, Vatier C, Bastard J-P, Fellahi S, Stévant M, et al.
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